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StrongHold 2012-5-11 08:39 PM

PH ADJUSTMENT

HELP ME PLEASE!!!
Mol. wt. of phenobarbital = 232.32
Mol. wt. of phenobarbital sodium = 254.22
Solubility of phenobarbital = 1g/L
Ka of phenobarbital = 3.9 x 10-8; pKa = 7.4

Phenobarbitone (MW 232) is a weak acid (pKa7.41),soluble about 1 in 1000 (0.0043M) in
water ,which is often used as its sodium salt (MW 254). this soluble salt is "incompatible with acid " ,
but the amount which will stay in solution depends on the pH of the final solution .
sodium Phenobarbitone has been reported to be incompatible with sodium bicarbonate in aqueous solutions
which would in usual concentrations have a pH value of about 8.2

How much Phenobarbitone will dissolve at pH 8.2 ?

[[i] 本帖最後由 StrongHold 於 2012-5-11 08:41 PM 編輯 [/i]]
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