查看完整版本 : MS 入面, MALDI-TOF 點解成日一齊用 ?

tc121091 2012-12-19 05:45 PM

MS 入面, MALDI-TOF 點解成日一齊用 ?

如題

MALDI 同 TOF 既原理
大概都知知地, 但諗唔到點解會經常link埋一齊用 :smile_27:
係因為大家都用 laser :smile_41:

Thank:smile_40:

jmlo 2012-12-20 12:16 AM

回覆 1# 的帖子

MALDI and TOF are concerned with different parts of a whole ion generation and analysis. MALDI is good at generating ions with large molecular sizes e.g. proteins, DNA, or polymers which easily crack when more powerful (or so-called hard) ionization tool is to be employed.

In the meantime, TOF-MS is a very nice approach which affords excellent separation of ions of same charge yet different masses since the time at which an ion reaches the detector is proportional to the square root of m/z.

As a result, the combined mode, MALDI-TOF-MS, is among the best instrumental technique for analyzing biomolecular samples.
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